A possible new role for fish retinal serotonin-N-acetyltransferase-1 (AANAT1): Dopamine metabolism

Jan 24, 2006Brain research

A possible new role for fish retinal serotonin enzyme in dopamine processing

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Abstract

AANAT1 from seabream and zebrafish can acetylate dopamine, suggesting a potential role in retinal function.

  • Two forms of the enzyme AANAT, AANAT1 and AANAT2, exist in teleost fish and may have different functions based on their varying expression patterns and substrate preferences.
  • Recombinant AANAT1s from seabream and zebrafish show similar kinetic characteristics when acetylating dopamine and tryptamine, while AANAT2s do not exhibit this activity.
  • High performance liquid chromatography analysis confirmed the presence of N-acetyldopamine in seabream retinal extracts.
  • Daily patterns of retinal melatonin and N-acetyldopamine production correlate with AANAT1 activity, indicating a rhythmic function.
  • In situ hybridization revealed that tyrosine hydroxylase is present in the inner nuclear layer, while AANAT1 is expressed in both the outer and inner nuclear layers of the retina.

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