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The arylalkylamine-N-acetyltransferase (AANAT) acetylates dopamine in the digestive tract of goldfish: A role in intestinal motility
An enzyme that modifies dopamine in the goldfish gut may help control intestinal movement
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Abstract
Daily rhythms in enzyme activity were observed, with AANAT showing rhythmic patterns in the goldfish foregut.
- Retinal AANAT and HIOMT activities exhibit daily rhythms, indicating their involvement in melatonin production.
- Foregut AANAT activity displays a daily rhythm, while liver and hindgut show significant but non-rhythmic AANAT levels.
- HIOMT activity is absent in the liver and gut, suggesting AANAT may have alternative functions beyond melatonin synthesis.
- Dopamine inhibits N-acetyltryptamine production in retinal, intestinal, and hepatic tissues, indicating competitive interactions.
- Goldfish liver and gut produce N-acetyldopamine in the presence of acetyl coenzyme-A and dopamine, highlighting AANAT's role in dopamine regulation.
- Dopamine, but not N-acetyldopamine, is found to regulate gut motility for the first time in fish.
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