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Abstract
Melatonin is associated with multiple roles in reproductive physiology and may help mitigate oxidative stress and inflammation during pregnancy.
- Melatonin functions as a potent antioxidant and anti-inflammatory agent.
- It plays a role in regulating mitochondrial function.
- The review covers its implications in major gestational disorders like preeclampsia, fetal growth restriction, gestational diabetes mellitus, and preterm birth.
- Melatonin acts through both receptor-mediated and receptor-independent mechanisms.
- Preclinical and emerging clinical data indicate that melatonin supplementation could be a safe and effective therapeutic strategy during pregnancy.
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