Melatonin and pregnancy in the human

May 20, 2008Reproductive toxicology (Elmsford, N.Y.)

Melatonin Levels and Their Role During Human Pregnancy

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Abstract

The nighttime serum concentration of melatonin shows an incremental change toward the end of pregnancy.

  • Melatonin is a hormone produced by the pineal gland that plays a role in regulating biological rhythms.
  • This small molecule crosses the placenta easily, providing essential information about light and dark cycles to the fetus.
  • Melatonin may function as a circadian rhythm modulator, endocrine modulator, immunomodulator, and antioxidant during pregnancy.
  • It appears to be essential for a successful pregnancy and may help address complications such as abortion, pre-eclampsia, and fetal brain damage.
  • Current scientific evidence supports a significant role for melatonin in human pregnancy.

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