Full text is available at the source.
Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder
Melatonin treatment reduces repetitive behaviors in a mouse model of autism
AI simplified
Abstract
Exposure to dim light at night (DLaN, 5 lx) disrupts locomotor activity rhythms and social behavior in Cntnap2 KO mice.
- DLaN exacerbated excessive grooming and diminished social preference in Cntnap2 mutant mice.
- DLaN altered the phase and amplitude of PER2:LUC rhythms in a tissue-specific manner in vitro.
- Daily melatonin treatment reduced excessive grooming to wild-type levels.
- Melatonin improved activity rhythms in the mutant mice.
AI simplified