Neurobiology of disease

Melatonin treatment reduces repetitive behaviors in a mouse model of autism

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Exposure to dim light at night (DLaN, 5 lx) disrupts locomotor activity rhythms and social behavior in Cntnap2 KO mice.

  • DLaN exacerbated excessive grooming and diminished social preference in Cntnap2 mutant mice.
  • DLaN altered the phase and amplitude of PER2:LUC rhythms in a tissue-specific manner in vitro.
  • Daily melatonin treatment reduced excessive grooming to wild-type levels.
  • Melatonin improved activity rhythms in the mutant mice.

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Funding

Competing interests

Declaration of competing interest Dr. Colwell received research funding from Takeda Pharmaceuticals from 2015 to 2017. The authors of this work have no financial interests related to this manuscript.
PubMed

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