Melatonin and zopiclone to help crew members sleep

Subjects slept an average of 370.2 minutes with melatonin and 373.3 minutes with zopiclone, compared to 339.5 minutes with placebo.

• Both melatonin and zopiclone increased sleep duration compared to placebo.
• Psychomotor performance was impaired immediately after awakening from sleep, regardless of drug condition.
• Performance in tasks related to reaction time, logical reasoning, and mental calculations was affected by sleep inertia.
• Recovery of performance to pre-sleep levels occurred within 1.25 hours for most tasks, and within 2.25 hours for multitasking.
• No significant differences in performance or subjective feelings of sleepiness and fatigue were observed between the drug conditions and placebo.

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