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Melinjo (Gnetum gnemon L.) seed extract induces uncoupling protein 1 expression in brown fat and protects mice against diet-induced obesity, inflammation, and insulin resistance
Melinjo seed extract increases heat-generating protein in brown fat and helps protect mice from obesity, inflammation, and insulin resistance caused by diet
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Abstract
Dietary melinjo seed extract (MSE) significantly suppressed high-fat diet-induced fat accumulation and improved insulin resistance in mice.
- MSE did not change energy intake or spontaneous physical activity in mice.
- HFD-induced hyperglycemia and hyperinsulinemia were significantly reduced with MSE supplementation.
- Lower scores for insulin resistance and hepatic triglyceride content were observed in MSE-supplemented mice compared to those on a high-fat diet without MSE.
- MSE supplementation increased the expression of thermogenic proteins in brown adipose tissue, suggesting enhanced thermogenesis.
- Markers of inflammation in adipose tissue were increased by a high-fat diet but suppressed by MSE.
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