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One day of high-fat diet causes fat buildup and insulin resistance in mouse brown fat tissue
Updated
Abstract
Within 1 day of a high-fat diet (HFD), BAT weight and lipid content increased.
- HFD feeding led to rapid insulin resistance in brown adipose tissue (BAT), as indicated by reduced insulin-stimulated glucose uptake.
- A tendency towards decreased uptake of triglyceride-derived fatty acids by BAT was observed after the onset of HFD.
- Mitochondrial mass and expression remained unchanged, but markers suggested a shift towards a more fused mitochondrial network after 3 days on HFD.
- Increased macrophage markers in BAT were noted after 3 days of HFD, indicating potential immune response involvement.
- An acute rise in core body temperature was observed following the switch to HFD, suggesting a rapid activation of thermogenesis in other metabolic organs.
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