Chinese medicine Jinlida granules improve high-fat-diet induced metabolic disorders via activation of brown adipose tissue in mice

Mar 24, 2019Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Chinese medicine Jinlida granules improve high-fat diet–related metabolism problems by activating brown fat in mice

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Abstract

Jinlida granules (3.8 g/kg) significantly activated brown adipose tissue thermogenesis in mice fed a high-fat diet.

  • JLD treatment reduced obesity and fat mass gain in high-fat diet-induced mice.
  • Improvements were noted in glucose and lipid balance, along with reduced liver fat and inflammation.
  • JLD was associated with enhanced mitochondrial production and fat breakdown in brown adipose tissue.
  • These findings suggest a potential role for JLD in addressing metabolic disorders linked to obesity and type 2 diabetes.

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