Mental health and health-related quality of life response to curcumin-probiotic drink powder co-supplementation in adults with overweight/obesity and metabolic syndrome: a four-arm randomised, double-blind, placebo-controlled, clinical trial

May 16, 2025The British journal of nutrition

Mental health and quality of life changes after taking a curcumin and probiotic drink in adults with overweight, obesity, and metabolic syndrome

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Abstract

Curcumin-probiotic co-supplementation significantly reduced stress (p = 0.001) and anxiety (p = 0.019) in adults with overweight/obesity and metabolic syndrome.

Participants receiving CurPro showed improved general health (p = 0.024) and overall health-related quality of life (HRQOL) scores (p = 0.011) compared to the placebo group.
No significant changes were observed for depression or specific HRQOL subdomains, including physical functioning and social functioning.
The trial included 128 adults, with 104 completing the 8-week intervention.
Curcumin and probiotics may have beneficial effects on mental health and HRQOL in individuals with metabolic syndrome.

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Metabolic syndrome (MetS) is associated with deteriorated mental health and health-related quality of life (HRQOL). Curcumin and probiotics improved MetS, mental health and HRQOL. The present study aimed to investigate the effect of curcumin-probiotic (CurPro) co-supplementation in the form of drink powder on mental health and HRQOL in adults with overweight/obesity and MetS. A four-arm, randomised, double-blinded, placebo-controlled clinical trial with factorial design was conducted for adults with overweight/obesity and MetS (128). Participants were randomly allocated into four groups to receive one drink powder sachet containing 1 g curcumin, 10colony-forming unit (CFU) probiotic (andstrains), CurPro (1 g curcumin and 10CFU probiotic) or placebo along with a low-calorie diet. Participants were assessed for dietary intake, physical activity, mental health and HRQOL before and after the study. After 8 weeks of intervention, 104 participants finished the study. The CurPro intervention reduced stress (= 0·001) and anxiety (= 0·019) and improved general health (= 0·024) and overall HRQOL (= 0·011) scores of participants in comparison with the Placebo group. Results were NS for depression and HRQOL subdomains such as physical functioning, role limitations due to physical problems, bodily pain, vitality, social functioning and role limitations due to emotional problems. Curcumin-probiotics co-supplementation could improve the mental health and HRQOL of adults with overweight/obesity and MetS. Further investigations in various populations or with different dosages or durations are recommended. n Lactobacillus acidophilus Lactobacillus rhamnosus P P P P9 9

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Mental health and health-related quality of life response to curcumin-probiotic drink powder co-supplementation in adults with overweight/obesity and metabolic syndrome: a four-arm randomised, double-blind, placebo-controlled, clinical trial

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