Association between mental work and biological aging: the mediating role of visceral adiposity index

Sep 8, 2025Innovation in aging

How Mental Work Links to Biological Aging Through Belly Fat Levels

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Abstract

Mental workers showed an increase of 1.52 years in biological age acceleration compared to manual workers.

  • Biological age acceleration was measured using two methods: and .
  • Mental work was linked to greater biological age acceleration, with KDMAge increasing by 1.52 years and PhenoAge by 1.46 years.
  • High labor intensity in mental workers correlated with increased biological age acceleration.
  • In manual workers, high labor intensity also resulted in increased biological age acceleration, with KDMAge increasing by 1.53 years.
  • (VAI) was found to mediate a portion of the relationship between mental work and biological age acceleration.

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Key numbers

1.52 years
Increase in
for mental workers vs. manual workers
1.46 years
Increase in
for mental workers vs. manual workers
20.9%
Mediation Percentage
Mediation of relationship by

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