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The Association Between Accelerated Biological Aging as Measured by KDMAge and PhenoAge and Digestive System Cancer Risk: A Cross‐Sectional Study Using NHANES Data (1999–2018)
Faster Biological Aging Linked to Higher Risk of Digestive System Cancer
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Abstract
acceleration is associated with a 1.59 times higher risk of digestive system cancer.
- A significant positive linear association exists between KDMAge acceleration and digestive system cancer risk.
- acceleration demonstrates a U-shaped nonlinear relationship with digestive system cancer risk, with minimal risk at -2.95.
- Both KDMAge and PhenoAge exhibit moderate predictive accuracy for digestive system cancer risk.
- The robustness of the nonlinear relationship between PhenoAge acceleration and digestive system cancer risk was confirmed through propensity score matching analysis.
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Key numbers
1.59
Increase in Risk
for associated with risk
0.683
for
Area under the receiver operating characteristic curve for
0.682
for
Area under the receiver operating characteristic curve for