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Abstract
Essence
Mescaline acutely disrupted cerebellar signaling, broadened brain connectivity, and altered sensory gating in awake rats.
Evidence
This acute preclinical BOLD fMRI and prepulse-inhibition study in awake rats found cerebellar-selective BOLD suppression, global hyperconnectivity involving the cerebellum, loss of normal BOLD responses to rewarding olfactory stimuli, and frequency-dependent acoustic gating changes of +27.6% at 4 kHz, +27.3% at 20 kHz, and -16.4% at 12 kHz.
Caveat
Because the findings come from an acute rat neuroimaging model, they may not generalize directly to human psychedelic effects.
Simplified
Psychedelic Science