Metabolic and bariatric surgery versus glucagon-like peptide-1 receptor agonist therapy: A comparison of cardiovascular outcomes in patients with obesity

Feb 18, 2025American journal of surgery

Heart health after weight-loss surgery compared to medication in people with obesity

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Abstract

MBS was associated with a lower hazard of cardiovascular disease compared to GLP-1 RA therapy.

  • The primary composite outcome of cardiovascular disease included heart failure, coronary artery disease, and cerebrovascular disease.
  • Patients undergoing metabolic and bariatric surgery had a hazard ratio of 0.54 for cardiovascular disease.
  • Incident heart failure was associated with a hazard ratio of 0.45 following metabolic and bariatric surgery.
  • Coronary artery disease showed a hazard ratio of 0.54 in patients who underwent metabolic and bariatric surgery.
  • Cerebrovascular disease was associated with a hazard ratio of 0.64 in the metabolic and bariatric surgery group.

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