Utilization patterns of glucagon like Peptide-1 receptor agonists prior to bariatric and metabolic surgery: a multicenter study

Nov 8, 2024Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

Use of glucagon-like peptide-1 receptor agonists before weight loss and metabolism surgeries across multiple centers

AI simplified

GLP-1 Therapies on OpenScience ↗PubMed ↗DOI ↗

Abstract

A history of glucagon-like-peptide-1 receptor agonist (G1RA) utilization was found in 63% of 434 metabolic and bariatric surgery candidates.

Liraglutide and Semaglutide were the most commonly used G1RAs among patients.
Younger age, type 2 diabetes, dyslipidemia, and no previous metabolic and bariatric surgery history were linked to higher rates of G1RA utilization.
Median maximal weight loss for patients on G1RA was 5.38 kg, with a mean duration of use of 19 weeks.
Patients using G1RA for six weeks or more had significantly greater weight loss compared to those using it for shorter periods.
GI-related adverse events were reported in 57.8% of patients, leading to over 95% discontinuation of G1RA due to insufficient weight loss and/or adverse effects.
Higher weight loss was observed in patients reaching the maximal recommended dose of both Liraglutide and Semaglutide.

AI simplified

BACKGROUND: Glucagon-like-peptide-1 receptor agonists (G1RA) have gained popularity as a treatment for weight loss in patients who are overweight or obese, but their utilization patterns and impact on candidates for metabolic and bariatric surgery (MBS) remain understudied.

OBJECTIVE: We aimed to investigate the prevalence, characteristics, and outcomes of patients with a history of G1RA utilization among MBS candidates.

SETTING: Five high-volume MBS centers in Israel.

METHODS: Data were collected retrospectively from February 1st, 2023, to September 30th, 2023. Demographic, clinical, and treatment data were analyzed to assess a history of G1RA use, associated factors, adverse events, and treatment outcomes.

RESULTS: Four hundred thirty-four MBS candidates were included in the study. A history of G1RA utilization was obtained in 275 (63%) MBS candidates, with Liraglutide and Semaglutide being the most commonly used agents. Younger age, type 2 diabetes mellitus, dyslipidemia, and no previous MBS history were associated with a higher rate of G1RA utilization. With these medications, median maximal weight loss was 5.38 kg, and mean duration of use was 19 weeks. Patients using G1RA for ≥6 weeks experienced significantly greater weight loss compared to those using it for shorter periods (6.3 ± 6.43 vs 1.65 ± 1.69; P < .001). GI-related adverse events were reported in 57.8% of patients. Over 95% of patients discontinued G1RA due to insufficient weight loss and/or adverse effects. Patients reaching the maximal recommended dose exhibited significantly greater weight loss versus patients who did not reach it for both Liraglutide (5.9 ± 4.98 kg vs. 3.9 ± 5.53 kg; P = .03) and Semaglutide (6.5 ± 7.8 kg vs. 2.5 ± 3.8 kg; P = .016).

CONCLUSION: Pre-MBS G1RA utilization and failure are prevalent among MBS candidates. Our study underscores the need for further research to understand the role of G1RA therapy in obesity management and the development of guidelines for its appropriate use in MBS candidates.

Full Text

Full text is available at the source.

View full text (XML) ↗View full text ↗

Utilization patterns of glucagon like Peptide-1 receptor agonists prior to bariatric and metabolic surgery: a multicenter study

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the glp-1 therapies brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the glp-1 therapies brief