Experimental dermatologyAug 21, 2024

Metabolic differences in common psoriasis and palmoplantar pustulosis

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Updated Mar 31, 2026

Abstract

This study included 93 patients (73 with psoriasis vulgaris and 20 with palmoplantar pustulosis) and matched healthy volunteers.

Psoriasis vulgaris patients exhibited increased levels of several metabolites, including , serotonin, and proline, compared to healthy volunteers.
Palmoplantar pustulosis patients had significantly elevated sarcosine levels relative to healthy volunteers.
Both psoriasis vulgaris and palmoplantar pustulosis patients showed a higher sarcosine/glycine ratio than healthy volunteers.
Pathway analysis indicated significant increases in metabolites related to amino acid metabolism and the urea cycle in psoriasis vulgaris patients.
Distinct metabolic profiles were identified between patients with psoriasis vulgaris and palmoplantar pustulosis and healthy volunteers.

Simplified

Psoriasis is a chronic inflammatory skin disorder with various subtypes, including psoriasis vulgaris (PV) and palmoplantar pustulosis (PPP). studies have provided insights into psoriasis pathogenesis. However, research on metabolomic alterations in PV and PPP patients is limited. We aimed to explore and compare the metabolic profiles of patients with PV and PPP to those of healthy volunteers (HVs). A single-centre retrospective cohort was constructed, comprising Korean patients with psoriasis and HVs matched by age and sex. Clinical information including demographics, disease severity, and comorbidities were collected. Plasma samples were subjected to targeted metabolic analysis using an Absolute IDQ®p180 kit, which quantified 188 metabolites, including amino acids and carnitines. Statistical significance was assessed using an independent t-test and chi-square test, with p-values adjusted by the Benjamini-Hochberg procedure. Pathway analyses were employed to gain a comprehensive understanding of the metabolite profile. This study included 93 patients (73 PV and 20 PPP) and an equal number of HVs. PV patients showed increased levels of , serotonin, propionylcarnitine, proline, aspartic acid, tyrosine, taurine, spermine and ornithine, but exhibited a decreased level of acetylcarnitine than matched HVs. Notably, sarcosine levels were significantly elevated in PPP patients. Furthermore, the sarcosine/glycine ratio was significantly higher in both PV and PPP patients than in HVs. Pathway analysis showed significant increases in metabolites involved in amino acid metabolism and the urea cycle in PV patients. In conclusion, this study demonstrated distinct metabolic profiles in PV and PPP patients compared to HVs, suggesting sarcosine as a potential biomarker for psoriasis.

Key numbers

2.37E‐09

Increased Level in PPP

Statistical significance comparing PPP patients to healthy volunteers

4.26

Increased Level in PV

Statistical significance comparing PV patients to healthy volunteers

Higher

Higher /Glycine Ratio

Ratio indicating GNMT activity relative to SARDH activity

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Metabolic differences in common psoriasis and palmoplantar pustulosis

Abstract

Key numbers

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