Harnessing Metabolism to Combat Neurodegeneration: Strategies for Reversing Age-Related Cognitive Decline

Age-related cognitive decline is increasingly associated with metabolic dysregulation.

• Mitochondrial dysfunction, oxidative stress, and impaired energy metabolism are central to the progression of neurodegenerative disorders.
• Therapies that boost mitochondrial function, including NAD precursors and AMPK activators, may improve neuronal energy balance and reduce oxidative damage.
• Metabolic interventions such as caloric restriction and ketogenic diets could enhance insulin sensitivity and promote autophagy, potentially improving cognitive function.
• These strategies may also reduce neuroinflammation by modulating immune responses and decreasing toxic protein accumulation.
• Lipid metabolism is important for maintaining neuronal integrity, with enhanced lipid turnover and optimized fatty acid profiles potentially improving synaptic plasticity.

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