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Abstract
A total of 408 plasma metabolites were analyzed to identify markers of age and longevity.
- Three hundred eight metabolites are linked to age.
- Two hundred fifty-eight metabolites show changes over time.
- Two hundred thirty metabolites are associated with extreme longevity.
- One hundred fifty-two metabolites are connected to mortality risk.
- Nineteen distinct signatures differentiate between metabolites related to compensatory aging mechanisms and those indicating cumulative damage.
- Network analysis highlights the significant role of essential fatty acids in linking lipids to other metabolic processes.
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