Metabolic age estimates predict health and lifespan: Comparing different machine learning methods

The metabolomic aging clock (MileAge) is associated with increased health risks and aging markers in a sample of up to 225,212 adults.

• MileAge reflects the difference between metabolite-predicted age and chronological age.
• Older MileAge is linked to greater frailty and shorter telomeres.
• Higher MileAge correlates with a greater likelihood of chronic illness and poorer self-rated health.
• Individuals with older MileAge have a higher all-cause mortality hazard (HR = 1.51; 95% CI, 1.43 to 1.59; < 0.001).
• The study utilized data from the UK Biobank, focusing on 168 plasma metabolites.

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