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Combined Treatment of Metformin and Resveratrol Promotes Myogenesis Through Increased Irisin Release in C2C12 Cells
Metformin and Resveratrol Together Help Muscle Cell Growth by Increasing Irisin Release
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Abstract
Combination treatment with metformin and resveratrol significantly increased MyoD, myogenin, Myh, and FNDC5 expression compared to metformin alone.
- The increase in irisin production was linked to the activation of the AMPK/SIRT1/PGC-1α pathway.
- Phosphorylation of AMPK and upregulation of PGC-1α and SIRT1 were observed with the combination treatment.
- MyoD, myogenin, and Myh showed significantly higher mRNA and protein expression levels in the combination treatment group.
- This combination treatment may enhance myogenesis.
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