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Methylation of Histone H3 on Lysine 4 by the Lysine Methyltransferase SET1 Protein Is Needed for Normal Clock Gene Expression
Adding methyl groups to a specific protein by SET1 is needed for normal daily clock gene activity
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Abstract
The expression of the frq gene is altered in strains lacking SET1 under both circadian- and light-regulated conditions.
- H3K4 methylation is implicated in the regulation of the frq gene by the circadian clock and light.
- A delay in the peak of H3K4me3 relative to frq expression suggests altered timing mechanisms.
- White Collar 2 (WC-2) remains associated with the frq promoter for a longer duration in strains lacking SET1.
- SET1 is required for DNA methylation at the frq promoter, linking it to H3K4 methylation.
- The findings support a model where SET1 influences chromatin structure to regulate the frq gene.
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