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The Histone H3 Lysine 9 Methyltransferase DIM-5 Modifies Chromatin at frequency and Represses Light-Activated Gene Expression
The enzyme DIM-5 changes DNA packaging at the frequency gene and reduces its activation by light
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Abstract
DNA methylation at the frq promoter is dependent on both the DNA methyltransferase DIM-2 and the H3K9 methyltransferase DIM-5.
- H3K9 trimethylation at frq peaks 30 minutes after light exposure.
- Strains lacking dim-5 exhibit increased light-induced transcription and more White Collar-2 associated with the frq promoter.
- Loss of H3K9 methylation leads to a phase advance in frq expression.
- The dim-5 deletion strain shows increased circadian-regulated conidia formation.
- A synthetic genetic interaction is observed between dim-5 and ras-1(bd).
- DIM-5 may play a role in regulating circadian output by modulating light responsiveness.
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