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Methylphenidate Modifies the Motion of the Circadian Clock
Methylphenidate changes how the body’s internal daily clock moves
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Abstract
Methylphenidate significantly increased activity in the mid-to-late night in young male mice.
- The drug led to a delay in the onset of activity and sleep relative to the light-dark cycle.
- After treatment ended, locomotor levels returned to baseline, but the phase angle of entrainment took at least a week to normalize.
- In constant darkness, methylphenidate lengthened the free-running period of both wheel-running and general locomotor rhythms.
- Post-treatment, the free-running period either remained stable or only partially reverted to baseline levels.
- Methylphenidate altered the electrical firing rate rhythms in the suprachiasmatic nucleus, causing a delay in the rhythm's trough and increased amplitude.
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