Time-shifting effects of methylphenidate on daily rhythms in the diurnal rodent Arvicanthis ansorgei

Chronic exposure to methylphenidate (MPH) in diurnal rodents delayed the onset of activity and body temperature rhythms.

• MPH treatment in Arvicanthis ansorgei resulted in larger delays in daily rhythms when administered during the first 6 hours of the light phase.
• Both general activity and body temperature rhythms were affected by MPH exposure, indicating a disruption in normal circadian patterns.
• The effects of MPH on daily rhythms may be influenced by the timing of administration in relation to the light-dark cycle.
• The study suggests that the diurnal rodent model may provide valuable insights into the effects of MPH on circadian rhythms related to ADHD treatment.

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