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Abstract
A total of 134 cycling genes were identified in Drosophila melanogaster that are involved in various biological processes.
- Circadian gene expression in Drosophila is governed by the CLOCK (CLK) transcription factor.
- All oscillating gene expression is under the control of clk, indicating no clk-independent circadian systems exist in these flies.
- Many clock-regulated genes are located in clusters and appear to be regulated together.
- A larger number of genes are affected in Clk mutant flies, suggesting clk's influence extends to other genetic networks.
- Only a small number of direct target genes were identified, implying that most of the circadian gene network is regulated indirectly by clk.
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