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Microautophagy of Cytosolic Proteins by Late Endosomes
Small-scale recycling of cell proteins by late-stage cell compartments
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Abstract
Distinct autophagic mechanisms control cytosolic protein delivery to late endosomes.
- A microautophagy-like process delivers soluble cytosolic proteins to late endosomes/multivesicular bodies.
- This process is selective and different from chaperone-mediated autophagy that occurs in lysosomes.
- Endosomal microautophagy relies on the ESCRT I and III systems for vesicle formation.
- Protein selection for this process is mediated by the chaperone hsc70, requiring its cationic domain for interactions with the endosomal membrane.
- Endosomal microautophagy may share molecular components with both endocytic and autophagic pathways.
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