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Molecular determinants of the crosstalk between endosomal microautophagy and chaperone-mediated autophagy
Molecular factors controlling the interaction between two cell recycling systems
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Abstract
Chaperone-mediated autophagy (CMA) and endosomal microautophagy (eMI) share a compensatory relationship in degrading cytosolic proteins.
- Both CMA and eMI recognize the same five-amino-acid motif in substrate proteins.
- The chaperone protein Bag6 plays a role in sorting and internalizing eMI substrates into late endosomes.
- Starvation affects the dynamics of Bag6 at the late endosome membrane and is associated with a decline in eMI activity.
- A coordinated function between CMA and eMI suggests that these pathways may interchangeably degrade specific subsets of proteins.
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