Microbial Dysbiosis and Pathogenic Interplay in the Gut-Vaginal Axis: Implications for Polycystic Ovary Syndrome: A Critical Review

Feb 19, 2026Current microbiology

Imbalance of Gut and Vaginal Microbes and Their Interaction in Polycystic Ovary Syndrome

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Abstract

PCOS affects more than reproductive health, influencing systemic inflammation and insulin resistance.

  • PCOS is the most common endocrine condition among reproductive-age women.
  • It is associated with irregular menstrual periods, increased hair growth, and pregnancy difficulties.
  • Recent research emphasizes the reciprocal interaction between gut and vaginal microbiota in PCOS.
  • Stress hormones may impact hormonal activity, potentially altering the vaginal and gut microbiomes.
  • Microbial population changes in these areas could contribute to inflammation and insulin resistance in PCOS patients.

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