Microbiome: A Key Regulator of Body-Brain Interactions

May 29, 2025Advances in experimental medicine and biology

The Microbiome's Role in Controlling Body and Brain Communication

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Abstract

The gut microbiota consists of trillions of microorganisms that significantly influence host physiology.

  • The microbiota-gut-brain axis connects gut microbial activity with processes in the central nervous system.
  • Communication occurs through immune pathways, metabolic byproducts, and neural circuits, including the vagus nerve.
  • Changes in gut microbiota are influenced by factors such as birth mode, antibiotic use, aging, and neurodegenerative conditions.
  • Gut microbiota may affect neurological conditions like autism spectrum disorder, anxiety, and Alzheimer's disease.
  • Microbiome-targeted therapies and emerging technologies may offer personalized strategies for improving brain health.

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Full Text

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