How gut microbe chemicals communicating through cell receptors may relate to brain degeneration

Dysbiosis may disrupt the synthesis of important microbiota-derived metabolites, which is associated with neurodegenerative disorders.

• The gut microbiome regulates host homeostasis and communicates with the brain via the gut-brain axis.
• Dysbiosis leads to microbial imbalance, affecting the production of metabolites like short-chain fatty acids and neurotransmitter precursors.
• Altered metabolite profiles may cause aberrant activation of G protein-coupled receptors, impacting crucial intracellular signalling pathways.
• This disruption can increase neuroinflammation, oxidative stress, mitochondrial dysfunction, and protein aggregation, all of which are linked to neurodegeneration.
• Identifying specific signalling pathways could provide insights for developing therapeutic strategies targeting the microbiome in neurodegenerative disorders.

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