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The microbiota–gut–brain axis in mild cognitive impairment and Alzheimer's disease: a scoping review of human studies
Gut bacteria and their link to thinking problems in mild cognitive impairment and Alzheimer's disease: a review of human studies
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Abstract
is a common feature of mild cognitive impairment (MCI) and Alzheimer's disease (AD).
- Increased levels of Pseudomonadota and Actinomycetota have been frequently reported in AD.
- Reduced microbial diversity is observed in some cases of MCI and AD.
- Beneficial bacteria such as Faecalibacterium and Roseburia are consistently lower in MCI and AD according to limited studies.
- Probiotic and dietary interventions may help in modifying both cognition and gut microbiota, though results are inconsistent.
- Emerging evidence suggests a link between gut dysbiosis and cognitive decline, but methodological differences and short follow-up periods limit causal conclusions.
- Future research should focus on standardized methods and long-term human studies to better understand the microbiome's therapeutic potential.
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Key numbers
58 studies
Study Inclusion
Final count of studies included in the review
1529 studies
Removed
Number of removed during the study selection process
4751 studies
Initial Studies Identified
Total studies identified during the initial search