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Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice
Probiotics change gut bacteria and increase liver bile acid production by lowering a specific feedback signal in mice
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Abstract
Gut microbiota modulation by VSL#3 probiotics enhances bile acid deconjugation and fecal excretion in mice.
- Probiotic treatment alters bile acid absorption in the ileum.
- The enterohepatic farnesoid X receptor-fibroblast growth factor 15 (FXR-FGF15) pathway is repressed following probiotic administration.
- Increased hepatic bile acid synthesis occurs in response to changes induced by the probiotics.
- Administering an FXR agonist normalizes fecal bile acid levels in mice treated with probiotics.
- Deficiency in FXR and FGF15 negates the probiotic effects on bile acid metabolism.
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