Full text is available at the source.
Abstract
The gut microbiota may play a crucial role in shaping neurodevelopmental outcomes across generations.
- Gut microbiota is associated with maternal influences on offspring brain and behavior.
- Temporal and intergenerational effects of gut microbiota on host physiology and neurobehavioral outcomes have been observed.
- Mechanisms such as epigenetic regulation and neurotransmitter modulation are involved in neuro-microbial-immunometabolic interactions.
- Maternal states like stress, diet, and inflammation could have long-term impacts on offspring neurodevelopment through the microbiota.
- A translational gap exists from animal models to humans regarding these effects.
- Integrating multi-omics and clinical approaches may help define developmental windows for targeted microbiota-based interventions.
Simplified