Carefully designed tiny capsules for steady release of mRNA lipid nanoparticles

Microcapsules encapsulating mRNA lipid nanoparticles extended mRNA expression in mice for up to 8 days after a single injection.

• Encapsulation of mRNA lipid nanoparticles in microcapsules may enhance their stability and retention in the body.
• The microcapsules were created using a customized microfluidic method, resulting in uniform size and shell thickness.
• In vitro tests indicated that the microcapsules effectively protected mRNA lipid nanoparticles and allowed for controlled release over longer periods.
• In vivo results showed significantly prolonged retention of mRNA in mice, suggesting improved delivery potential.
• This microcapsule-based system could lead to better therapeutic outcomes and reduced need for frequent injections.

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