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Origin and turnover of microglial cells in fibrillar plaques of APPsw transgenic mice
Where microglial cells come from and how they renew in amyloid plaques of Alzheimer’s model mice
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Abstract
The number of microglial cells in plaques increases from 1 or 2 in early plaques to more than 100 in older plaques.
- Microglial cells are found in fibrillar plaques in the brains of Alzheimer's disease patients and transgenic mice.
- Cored plaques primarily develop in perivascular regions, indicating a link between blood vessels and plaque formation.
- Plaques appear to be formed by inflammatory cells that originate from the blood.
- An increase in microglial cells is associated with growth of amyloid cores and neuronal degeneration.
- A notable turnover of inflammatory cells occurs in larger plaques, particularly at the boundary with blood vessels.
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