Cells of monocyte/microglial lineage are involved in both microvessel amyloidosis and fibrillar plaque formation in APPsw tg mice

Plaque growth in APP(SW) transgenic mice is associated with an increase in microglial cells from 2 to 113 in the largest plaque.

• Amyloid deposition occurs in capillary walls and perivascular plaques, indicating a shared pathological process.
• The growth of microglial cells does not lead to the degradation of amyloid deposits.
• An increase in the number and volume of microglial cells correlates with plaque volume growth from 1555 to 284,497 microm(3).
• Microglial cells do not exhibit morphological evidence of internalizing or degrading fibrillar amyloid.
• The findings suggest that both capillary amyloidosis and plaque formation may involve similar mechanisms.

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