microRNAs expression correlates with levels of APP, DYRK1A, hyperphosphorylated Tau and BDNF in the hippocampus of a mouse model for Down syndrome during ageing

Increased APP expression in the hippocampus of 5-month-old Down syndrome mice may correlate with decreased levels of specific miRNAs.

• In 5-month-old Down syndrome mice, increased APP expression is associated with lower levels of miR-17, -20a, -101, and -106b.
• At 2 months of age, normal APP expression coincides with higher levels of miR-17, -101, and -106b in Down syndrome mice.
• Increased DYRK1A mRNA levels in 5-month-old Down syndrome mice are associated with decreased miR-199b levels.
• Higher DYRK1A levels in these mice correlate with increased phosphorylation of Tau at the Thr212 residue.
• Tau pathology in 5-month-old mice is characterized by decreased BDNF expression and increased miR-26a/b levels.
• miR-17, -20a, -26a/b, -101, -106b, and -199b could be potential targets for addressing Tau and amyloid beta pathology in Down syndrome.

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