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Middle-aged mice show delayed and destabilized food-anticipatory circadian activity under restricted feeding
Middle-aged mice have slower and less stable daily activity before scheduled feeding
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Abstract
Food-anticipatory activity (FAA) emerged significantly earlier in 12-week-old mice compared to 54-week-old mice during restricted feeding.
- Mice typically exhibit nocturnal activity and feeding patterns under normal conditions.
- Under a 4-hour daily feeding schedule, younger mice demonstrated earlier FAA than older mice.
- After resuming ad libitum feeding, younger mice shifted their daytime activity back to nocturnal rhythms more effectively than older mice.
- Some middle-aged mice displayed unstable patterns in their activity rhythm after returning to normal feeding.
- These findings suggest that FAA is regulated by a circadian system that operates independently of the suprachiasmatic nucleus.
- Aging may delay and disrupt the expression of FAA.
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