miR-126-3p sensitizes glioblastoma cells to temozolomide by inactivating Wnt/β-catenin signaling via targeting SOX2

MiR-126-3p expression was decreased in temozolomide-resistant glioblastoma tissues and cells.

• High levels of miR-126-3p enhanced sensitivity to temozolomide by inhibiting cell viability and inducing apoptosis.
• SOX2 was identified as a downstream target of miR-126-3p, with its overexpression linked to increased temozolomide resistance.
• The sensitivity to temozolomide conferred by miR-126-3p was reversed when SOX2 expression was increased.
• MiR-126-3p was associated with the inactivation of Wnt/β-catenin signaling, which was diminished by SOX2 up-regulation.

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