MiR-4787-5p Regulates Vascular Smooth Muscle Cell Apoptosis by Targeting PKD1 and Inhibiting the PI3K/Akt/FKHR Pathway

miR-4787-5p is highly expressed in aorta tissues of patients with aortic dissection compared to those from healthy donors.

• Vascular smooth muscle cell dysfunction is a primary factor in aortic dissection.
• Overexpression of miR-4787-5p significantly increases apoptosis in vascular smooth muscle cells.
• Polycystic kidney disease 1 gene (PC1) is identified as a direct target of miR-4787-5p in these cells.
• The PI3K/Akt/FKHR signaling pathway is inactive in aortic tissues affected by aortic dissection.
• Knockdown of miR-4787-5p reduces vascular smooth muscle cell apoptosis, suggesting a potential mechanism for its effects.

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