Efficacy of mirtazapine in clinically relevant subgroups of depressed patients.

Mirtazapine demonstrates good antidepressant efficacy and excellent tolerability in clinical trials.

• Placebo-controlled trials indicate mirtazapine is effective for moderately or severely depressed patients.
• It may be particularly beneficial for anxious patients, those with sleep disturbances, retarded patients, and agitated patients.
• The pharmacological profile of mirtazapine is associated with its efficacy and tolerability.
• Antidepressant activity may arise from its dual action on noradrenergic and serotonergic neurotransmission.
• Anxiolytic and sleep-improving effects could be due to the blockade of specific serotonin receptors.

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