Mitigating muscle loss during weight loss: can nutritional ketosis make a difference? A call for more research

Weight loss with incretin mimetic-based therapies may lead to disproportionate loss of lean body mass.

• Preserving lean body mass during weight loss is crucial for maintaining muscle function and metabolic health.
• High adherence to a ketogenic diet is associated with reduced lean body mass loss and improved physical function during significant weight loss.
• Further research is needed to understand how nutritional ketosis helps preserve lean body mass.
• The role of other lifestyle interventions in lean body mass preservation during weight loss requires additional exploration.
• Future studies should evaluate lean body mass, physical function, and frailty in various weight loss interventions.

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