Methods in molecular biology (Clifton, N.J.)Jun 7, 2021

Treatment Approaches Targeting Mitochondria in Nonalcoholic Fatty Liver Disease

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated Apr 4, 2026

Abstract

Mitochondrial dysfunction is involved in the progression of nonalcoholic fatty liver disease (NAFLD) to more severe liver conditions.

NAFLD is a prevalent chronic liver disease in developed countries that can lead to serious complications.
Liver mitochondria may be a key target for treatments aimed at enhancing liver function in NAFLD patients.
Current therapeutic options for NAFLD are discussed, based on both experimental and clinical evidence.
Novel strategies for improving mitochondrial function in NAFLD are presented.

Simplified

Nonalcoholic fatty liver disease (NAFLD) is one of the most frequent metabolic chronic liver diseases in developed countries and puts the populations at risk of progression to liver necro-inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma. Mitochondrial dysfunction is involved in the onset of NAFLD and contributes to the progression from NAFLD to nonalcoholic steatohepatitis (NASH). Thus, liver mitochondria could become the target for treatments for improving liver function in NAFLD patients. This chapter describes the most important steps used for potential therapeutic interventions in NAFLD patients, discusses current options gathered from both experimental and clinical evidence, and presents some novel options for potentially improving mitochondrial function in NAFLD.

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Treatment Approaches Targeting Mitochondria in Nonalcoholic Fatty Liver Disease

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