Mitochondria’s role in immune response and treatments during long COVID

Mutations in mitochondrial genes can disrupt key cellular functions and may contribute to various complex diseases.

• SARS-CoV-2 infection is associated with mitochondrial dysfunctions, including increased release of reactive oxygen species (ROS).
• The formation of the NLRP3 inflammasome may occur as a result of mitochondrial disruptions during COVID-19.
• Impairments in the process of removing damaged mitochondria (mitophagy) could be linked to the disease.
• Activation of the mitochondrial apoptotic pathway is suggested as a consequence of the infection.
• The ongoing inflammatory state may contribute to cardiac, muscular, and neurological complications following COVID-19.

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