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Abstract
Mitochondrial dysfunction is associated with stem cell exhaustion and chronic inflammation.
- Mitochondria play a crucial role in regulating aging by affecting energy production, immune signaling, and stem cell function.
- Age-related mutations in mitochondrial DNA can impair cellular respiration and alter the availability of metabolites, impacting stem cell activity.
- Loss of mitochondrial quality control allows harmful reactive oxygen species to accumulate, which may lead to increased inflammation.
- Mitochondrial damage can trigger inflammatory responses by activating specific cellular signaling pathways, contributing to chronic inflammation.
- Nicotinamide adenine dinucleotide (NAD⁺) depletion may hinder cellular resilience and promote a state of senescence linked to mitochondrial dysfunction.
- Emerging strategies targeting mitochondria, such as NAD⁺ repletion and mitochondrial engineering, offer potential avenues for improving healthspan.
Simplified
Longevity & Aging