Full text is available at the source.
Abstract
Alzheimer's disease is characterized by three key pathological features: amyloid-β deposition, tau hyperphosphorylation, and neuronal loss.
- Mitophagy deficiency and calcium imbalance are crucial factors in the progression of Alzheimer's disease.
- Impaired mitophagy leads to the buildup of damaged mitochondria, worsening calcium imbalance.
- This detrimental cycle can accelerate the formation of amyloid-β plaques and neurofibrillary tangles.
- The interaction between mitophagy impairment and calcium dyshomeostasis may contribute to neuronal death and cognitive decline.
- Potential intervention strategies aim to correct mitophagy and calcium regulation, offering insights for future Alzheimer's treatments.
Simplified