Molecular architecture of the mammalian circadian clock

Circadian clocks coordinate physiology and behavior with the 24h solar day.

• Molecular clocks are structured around interlocked feedback loops that regulate internal timing.
• These clocks integrate various environmental and metabolic signals to maintain a 24-hour rhythm.
• Recent advances reveal the core molecular clock employs multiple transcriptional and post-transcriptional mechanisms.
• Insights into biological rhythms may lead to new strategies for timing therapeutic interventions.

AI simplified