Advanced drug delivery reviews

The body’s internal clock: Basic workings and potential treatments for brain disorders

Updated

Abstract

Circadian rhythm disruption may be linked to numerous neurological conditions.

  • Circadian rhythms are biological processes regulated by a molecular clock that aligns with a 24-hour light-dark cycle.
  • Disruption of these rhythms can impact cognitive and metabolic functions.
  • Core clock feedback loops and regulatory pathways govern the circadian clock's function.
  • Synchronization of peripheral tissue clocks to the suprachiasmatic nucleus occurs through neuronal and hormonal pathways.
  • Dysregulation of circadian rhythms is associated with various neurological conditions.
  • Potential therapeutic treatments targeting circadian mechanisms may help restore rhythms and alleviate neurological symptoms.

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Full Text

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Funding

Competing interests

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: AJ is a founder Circadian Therapeutics Ltd. and hold shares in the company.
PubMed

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