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Why mRNA-ionizable LNPs formulations are so short-lived: causes and way-out
Why mRNA lipid nanoparticles have a short lifespan: causes and possible solutions
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Abstract
The stability of mRNA-ionizable lipid nanoparticles (LNPs) during long-term storage remains uncertain.
- mRNA and siRNA can undergo various physical processes without degradation.
- The acidity of the environment helps ionizable lipids protect mRNA, but storage stability is not well understood.
- Ionizable LNPs may face instability due to formulation excipients during prolonged storage.
- Possible methods to extend the shelf life of mRNA-ionizable LNPs include advanced drying processes and new hybrid formulations.
- Enhancements in storage could lead to safer and more stable mRNA-ionizable LNPs at room temperature.
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