Multiple Photopigments Entrain the Mammalian Circadian Oscillator

Mar 3, 2007Neuron

Several light-sensitive proteins help set the mammal's internal body clock

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Abstract

Medium wavelength opsin (MW-opsin) plays an important role in circadian photoentrainment.

  • Circadian rhythms are influenced by the natural day:night cycle.
  • Melanopsin in retinal ganglion cells contributes to this photoentrainment.
  • MW-opsin is identified as another key player in the entrainment process.
  • A model is developed to explain how different wavelengths affect photoentrainment involving both melanopsin and MW-opsin.

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